43 in 16 cases of atypical fibroxanthoma (AFX). For the immunohistochemical staining, a tissue array was obtained from the paraffin‐embedded blocks. Results. The expression was membranous and cytoplasmic in all cases. Thirteen cases (81.25%) showed strong staining.
A weeping, or sometimes bleeding growth, or multiple lumps, may grow over a few months on the head or neck area. The lumps may be pink or red in colour. They can be ulcerated or crusted. It is not commonly painful or sore or itchy. Pathology. Atypical fibroxanthomas are fibrohistiocytic skin tumors with a wide range of appearances on histological examinations and a certain histological similarity to squamous cell carcinoma. The diagnosis requires skin biopsy with careful evaluation to differentiate it from other skin tumors, Radiographic features Stanford Medicine » School of Medicine » Departments » Surgical Pathology Criteria » Superficial Acral Fibromyxoma Navigation for This Section: Surgical Pathology Criteria Diagnostic Criteria PathologyOutlines.com, Bingham Farms, MI. 22,957 likes · 538 talking about this.
Usually presents on the sun exposed skin (e.g. head and neck) of elderly patients with a slight male predominance. Histologically, a dermal based, well circumscribed tumor composed of pleomorphic, irregularly arranged, spindled to epithelioid cells with numerous mitotic figures.
Mitotic figures frequent, many of which are atypical. The behavior of atypical fibroxanthoma is benign, if strict diagnostic criteria are applied.
Leiomyosarcoma : Usually positive for smooth muscle markers, such as smooth muscle myosin and desmin. Metastatic carcinoma :
Also atypical fibroxanthoma (focal), hemangiopericytoma (scattered), myofibroblastoma in lymph nodes (variable), pleomorphic hyalinizing angiectatic tumor (focal), storiform collagenoma (scattered)
Atypical fibroxanthoma (AFX) occurs in the sun-exposed skin of the elderly and follows a benign clinical course. Histologically, AFX, which is a pleomorphic spindle cell tumor and considered to be a superficial variant of malignant fibrous histiocytoma, also mimics leiomyosarcoma. Atypical fibroxanthoma often appears in areas that have received excessive sun exposure, usually around the scalp, ears, nose, cheeks, and back of the neck, or in areas where individuals may have previously received radiotherapy treatment.
Abstract. Atypical fibroxanthoma and undifferentiated pleomorphic sarcoma, or pleomorphic dermal sarcoma, are rare malignant cutaneous neoplasms existing along a clinicopathologic spectrum. Although these tumors share many similarities, recognition of distinguishing characteristics may predict differences in clinical behavior and outcomes.
0/22. Atypical fibroxanthoma. 0/22. Malignant fibrous histiocytoma.
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H&E stain. LM. dermal lesion with marked nuclear atypia, mitoses, mulitnucleated cells, cell have foamy cytoplasm. LM DDx. malignant melanoma, pleomorphic undifferentiated sarcoma, leiomyosarcoma, sarcomatoid squamous carcinoma. IHC. INTRODUCTION Atypical fibroxanthoma (AFX) is an uncommon, pleomorphic, spindle cell cutaneous malignancy that most commonly presents as a solitary red or pink papule or nodule on the head or neck (picture 1A) [ 1 ].
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Cytomorphologically, lesional cells are highly bizarre and atypical, with marked pleomorphism in size and including basal cell carcinomas,4 Kaposi sarcoma,5 indeterminate fibrohistiocytic tumors,6 and atypical fibroxanthoma (AFX). Weedon D: Skin Pathology. Dec 11, 2019 metaphyseal fibrous defect; nonosteogenic fibroma; cortical desmoid; fibrous cortical defect; fibromatosis; fibroxanthoma. Epidemiology. Mar 16, 2021 Skin nonmelanocytic tumor - Atypical fibroxanthoma (AFX), Rare, low grade, malignant cutaneous tumor of uncertain differentiation, first Silverberg's Principles and Practice of Surgical Pathology and Cytopathology - March fibrous histiocytoma, atypical fibroxanthoma (superficial malignant fibrous perineurial tissue admixed in the process and outlining each smal Aug 16, 2016 Here's my sample pathology report template for AFX vs pleomorphic dermal sarcoma: https://kikoxp.com/posts/5193.
Atypical fibroxanthomas and pleomorphic dermal sarcomas are tumors arising in sun-damaged skin of elderly patients.
Despite its highly atypical histological appearance it is almost always associated with innocuous clinical behaviour. AFX is now generally regarded as the superficial counterpart of undifferentiated pleomorphic sarcoma (so-called malignant Herein, we present a study on the immunohistochemical expression of connexin (Cx) 43 in 16 cases of atypical fibroxanthoma (AFX).